Dott.ssa Lorena POCHINI
 

 

Researcher in Biochemistry

SSD: BIO/10

DiBEST
Ponte Pietro Bucci
Cubo 33C – floor 6

PHONE: +39 0984/496040

EMAIL: lorena.pochini@unical.it

 

   RESEARCH INTERESTS

 

 - Heterologous expression (P. pastoris) and purification of human plasma membrane transporters of amino acids;
 - Proteoliposomes as tool for assaying membrane transporter functions and interactions with xenobiotics.
 - Transporter as drug target in anticancer therapy, Crohn’s disease, etc.
 - SLC38A9: the lysosomal sensor of amino acid levels involved in mTORC1 activation.
 - Structure/function studies on transport proteins;
 - Drug design: the effect of xenobiotic compounds on membrane transport protein activity.


Principal proteins under investigation:
 I) Carnitine Transporters: OCTN2, OCTN3, CACT
 II) Amino acid transporters: ASCT2, B°AT1, LAT1, ATB0+, SNAT9
 III) Organic cation and acetylcholine transporter: OCTN1
 IV) Sialic Acid transporter from bacteria SiAT

 

 

   LABORATORIES

 

-          - Unit of Biochemistry and Molecular Biotechnologies Cubo 4C IV floor;
 - Unit of Molecular Biology and Microbiology Cubo 6C V floor.

 

 

   PUBBLICATIONS

 

-            https://www.ncbi.nlm.nih.gov/pubmed/?term=pochini+l

 

 

   TEACHING COURSES

 

 - Enzymology and Biochemical Diagnostics - Master Degree, Course in Biology

 - Advanced Molecular Diagnostics - Master Degree, Course in Biotechnology for Health

 - Biochemistry of the pathological states - First degree, Course in Biology