Prof.ssa Lorena POCHINI
 

 

Associate Professor of Biochemistry

SSD: BIO/10

DiBEST
Ponte Pietro Bucci
Cubo 4C – floor 4

PHONE: +39 0984/492940

EMAIL: lorena.pochini@unical.it

 

   RESEARCH INTERESTS
- Heterologous expression (P. pastoris) and purification of human plasma membrane transporters of amino acids;
- Proteoliposomes as tool for assaying membrane transporter functions and interactions with xenobiotics.
- Transporter as drug target in anticancer therapy, Crohn’s disease, etc.
- SLC38A9: the lysosomal sensor of amino acid levels involved in mTORC1 activation.
- Structure/function studies on transport proteins;
- Drug design: the effect of xenobiotic compounds on membrane transport protein activity.


Principal proteins under investigation:
I) Carnitine Transporters: OCTN2, OCTN3, CACT
II) Amino acid transporters: ASCT2, B°AT1, LAT1, ATB0+, SNAT9
III) Organic cation and acetylcholine transporter: OCTN1
IV) Sialic Acid transporter from bacteria SiAT

 

   LABORATORIES

- Unit of Biochemistry and Molecular Biotechnologies Cubo 4C IV floor;
- Unit of Molecular Biology and Microbiology Cubo 6C V floor.

 

   PUBBLICATIONS

 https://www.ncbi.nlm.nih.gov/pubmed/?term=pochini+l

 

   TEACHING COURSES

27006548 - DIAGNOSTICA MOLECOLARE AVANZATA - Doc. POCHINI Lorena (CdS 0781 GENERICO)
27002161 - ENZIMOLOGIA E DIAGNOSTICA BIOCHIMICA - Doc. POCHINI Lorena (CdS 0734 Patologico-molecolare)