The University of Calabria is pleased to offer an innovative interdepartmental and interdisciplinary Ph.D. program in Translational Medicine based in the Department of Pharmacy and Health and Nutritional Sciences.
The goal of the program is to prepare individuals for the careers of PhD and MD/PhD scientists as leaders in the field of clinically based research, which advances the translation of discoveries arising from post-genomics, structural genomics, gene function and model organisms into a mode of delivery that will benefit human health.
About Translational Medicine
Translational Medicine, or translational science, is a rapidly growing academic and scientific discipline in biomedical research.
For many years, extensive national resources have been devoted to basic biomedical (bench) and clinical (human subject) research; however, significant barriers continue to exist in moving knowledge bi-directionally between basic research, clinical research, and applications to improve health outcomes in individuals and the community. These barriers make it difficult to efficiently and effectively translate new knowledge into improved patient care.
To remedy these problems, Translational Medicine builds on basic research advancesand uses them to develop new therapies or medical procedures, thus carrying scientific knowledge “from bench to bedside”.
Translational medicine has gained a key role in translating basic life science discoveries into therapeutic applications. Nevertheless, the establishment of firm links between fundamental and medical research and the exploitation of knowledge, advanced technologies and their outfalls is still very difficult due to the lack of specific translational medicine training programs.
The proposed PhD program will support the development of translational medicine, foster advanced genomics, proteomics and biotechnology and their applications to experimental medicine, contributing to forward its translational medicine applications to human diseases.
About the PhD Program in Translational Medicine
The mission of the Translational Medicine Program is to provide state-of-the-art didactic and research trainingwhich prepares individuals for academic and clinical careers relating to the translation of basic biomedical research into clinical strategies to improve health.
Within the program, novel hybrid researchers will be trained at the European level to rapidly translate scientific advances to the patient’s advantage.
Building such international translational highways requires innovative educational models and career paths, with the aim of providing cross-disciplinary training for PhDs and MDs with potential bench-to-bedside round trips.
Through feedback from clinical situations, program graduates will also target and stimulate basic scientific research in pursuit of causes of disease and optimal therapies to prevent and cure disease.
Specific Program Objectives include:
Prepare individuals in fundamentals of the translation of basic biomedical research into clinical strategies to improve health
Provide in-depth mentoring to assure productive research training
Provide research opportunities which enhance creative and global thinking in the design of research projects through a molecular genetic approach
Teach fundamental theory and knowledge in the subject areas essential to clinical research
Provide a critical environment fostering inquiry, integrity, teaching and communication skills, high productivity, and working in a multi-disciplinary environment.
Particular emphasis is placed on translational and interdisciplinary applications consistent with the development of experimental protocols in vivo and in vitro and in animal models. These are engineered to provide adequate validation of new pathological markers of targeted therapeutical strategies in a broad spectrum of chronic degenerative diseases in the areas of oncology, neuroscience and cardiovascular diseases.
The experimental models enable the design of preclinical and clinical studies on biomarkers of early stage, drugs and biomolecular systems able to promote a prompt and accurate diagnosis. In this context, the programming on technology advanced basis (self-factory, computational chemistry of new molecules) can be used as diagnostic and therapeutical clinical tools.
The PhD Program is, thus, organised into the following 2 curricula pathways:
1. Molecular basis of diseases and pharmacological approaches for Translational Medicine;
2. The design of innovative molecules for both diagnostic and clinical use.
The experimental approach focusing on cellular and subcellular mechanisms is combined with the physiological and pathophysiological analysis of the organism as a whole. Particular emphasis is placed on the integration between experimental and clinical research, aimed at facilitating the translation of scientific results into novel or more efficacious diagnostic and therapeutic applications.
Research aimed at discovering and testing new therapeutic agents, which include traditional small molecules as well as nano-vectors, both synthetic and biological is a relevant component of the PhD Program.
PhD candidates will attend to their chosen research project in the School labs and in those of associated institutions, working under the supervision of a tutor. Students will be involved in a host of activities - from journal clubs, workshops and training sessions in communication skills to a full spectrum of lectures organised during the PhD program with a strong international representation. Participation in these activities is mandatory.
Opportunities to carry out stages for complementary training in allied laboratories in the country or abroad are also provided by the PhD program.
Upon completion of their PhD studies, individuals will have acquired the training and understanding of biomedical systems required to successfully conduct integrative translational research.
Università della Calabria
via Pietro Bucci
87036 Arcavacata di Rende, Cs