DFSSN

Dipartimento di
Farmacia e Scienze della Salute e della Nutrizione
Dipartimento di Eccellenza L. 232/2016

  • Dipartimento di Farmacia e Scienze della Salute e della Nutrizione

 

 

 

 

 

 

 

 

 

Prof Vincenzo PEZZI

 

Education and Professional Experience

EDUCATION AND PROFESSIONAL EXPERIENCE

1984-1989- MS Biology cum laude- Faculty of Sciences - University of Calabria (Unical)

1989-1992 - Post-graduate specialization course in Biomedical Technology - University of Naples

1991 - 1995 Fellow Faculty of Pharmacy – Unical

1995 - 1996 Research fellow - Lab of Prof. William E. Rainey, SWT Medical Center - Dallas 

1997 - 1998 Fellow Faculty of Pharmacy – Unical

1999 - 2003 Assistant Professor of General Pathology – Dep. Pharmaco-Biology – Unical

2003 - 2010 Associate Professor of Applied Biology Dep. Pharmaco-Biology – Unical

2011 - Present Full Professor of Applied Biology Dep. Pharmacy, Health and Nutritional Sciences Unical

 

HONOURS AND INSTITUTIONAL RESPONSABILITY

2008-2013 Coordinator of course on Nutritional Sciences (two years Master degree)

2007-2011 Elected member of the Administrative Council of the University of Calabria as Representative of Associate  Professors.

2010- 2011 President of the Budget Commission of the Administrative Council of the University of Calabria

2007-2012 Elected  Member of Accademic Senate of University of Calabria

2011-2012 Vice-Director of the Dep. Pharmaco-Biology, Unical 

2014 – 2016 Elected Member of the executive committee  for “Associazione Italiana di Biologia e Genetica generale e molecolare (AIBG)”

2015 Visiting Professor (October) Department of Molecular & Integrative Physiology and Internal Medicine Endocrine Neoplasia Basic Research Unit -University of Michigan in Ann Arbor.

2016 – 2018 Selected Member of the Qualification Committee for the national scientific qualification (abilitazione scientifica nazionale) as Associate or Full Professor of Applied Biology (sector 05/F1).

2020-Present  Member of the Administrative Council of University of Calabria

 

Research Activity

MAIN­_RESEARCH_EXPERIENCE
Prof. Pezzi was Research Fellow in the Prof. William Rainey’s Lab, in Dallas and during that period, using the adrenal cancer cell line H295R as experimental model, he worked on molecular mechanisms regulating the expression of enzymes involved in adrenal steroidogenesis, contributing to clarify the pathways involved in these processes. The collaboration with Prof. Rainey's Lab in this field is still ongoing and has yielded the publication of 12 full papers.

 In 1999 he became assistant Professor of General Pathology at the University of Calabria and from that period on his main research interest has focused on molecular mechanisms regulating the expression of aromatase in several normal and tumor tissues, such as testis, breast, ovary and adrenal tissues. On this topic Prof. Pezzi is co-author of 12 full papers. Some of these studies were carried on in collaboration with prestigious and international research labs such as the one headed by Prof. Evan Simpson and Dr. Colin Clyne (PHIMR, Monash Medical Center Clayton, Australia).

In 2001 he started a collaboration with the labs of Prof. Francesco Fallo from Faculty of Medicine at the University of Padova, which have years of experience on basic and clinical research on adrenal tumors and a large availability of normal adrenocortical tissues and tumor tissues. Thanks to this collaboration we proved overexpression of aromatase and ER in adrenocortical tumors and highlighted the ability of estradiol to enhance H295R cells proliferation. This collaboration allowed to publish 9 full papers and is still active. In the last years his research focused mainly on the study of signaling pathways involved in ACC growth. To support his research from 2011 he received  three grants funded by AIRC. Moreover thanks to another project funded by Italian University Minister (MIUR, FIRB), his research group investigated in collaboration with others Italian research teams several molecular mechanisms involved in the genesis and progression of ACC. Recently, in collaboration with Prof. Lisanti’s lab, at the University of Manchester, UK, Prof. Pezzi started to investigate the potential master regulators involved in reprogramming metabolism in endocrine tumors including ACC.

 

GRANTS FROM COMPETITIVE CALLS OBTAINED AS PRINCIPAL INVESTIGATOR (PI)

2005-2008 PI of one operative unit of the project: "Effects of environmental pollutants on the process of spermatogenesis and semen quality"  funded by EU-Calabria Region (POR) € 50.000. 
2005-2008 PI of one operative unit of the project: "Environmental and biological monitoring of benzene exposure of police officers in Rende-Cosenza area" funded by EU-Calabria Region (POR) €50.000.

2005-2007 PI of one operative unit of the project "Antitumor activity of polyphenol extracts from olive oil" in the project RIOM: "Research and innovation for the olive growing Southern Italy", funded by the Program of Development of the South Italy 2004 -2007 € 25.000.

2008-2009 PI of one operative unit of the project: "Effects of anabolic steroids and their functional interactions with growth factors in the development and progression of testicular tumors" funded by the Italian Ministry of Health € 50.000.

2011-2013 PI of the project: "Integration of signaling pathways in adrenocortical carcinomas: New insights for new therapeutic approaches". Funded by AIRC (Italian Association for Research on Cancer) € 180.000.

2011-2014 PI of the operative unit Cosmetic and Pharmaceutical application of the project: Development of new technology process to use biological olive oil”. Granted by MIUR – (PON) € 100.000.  

2013-2014 PI of the project: “Estrogen Receptors as innovative target for the treatment of Adrenocortical Carcinoma” granted by EU (POR) € 75.000.

2014-2016 PI of the project: "Selective estrogen receptor modulators (SERMs): a new tool for targeted therapy in adrenocortical cancer". Funded by AIRC (Italian Association for Research on Cancer) in collaboration with Prof. William E. Rainey University of Michigan in Ann Arbor € 195.000

2018-2022 PI of the project: “Estrogen Related Receptor α (ERRα) a key metabolic factor as target to prevent Adrenocortical Cancer progression” Funded by AIRC (Italian Association for Research on Cancer) in collaboration with Prof. Lisanti’s lab, at the University of Manchester, UK, € 414.000.

 

FELLOWSHIP, SCIENTIFIC COLLABORATION AND AWARDS

1995-1996 Research fellow - Lab of Prof. William E. Rainey and Prof. Bruce Carr Department of Obstetrics and Gynecology - Division of Reproductive Endocrinology - UTSW Medical Center - Dallas – Texas

1996 Visiting research scientist (November) Lab of Prof. Serge Carreau Dep. Biochimie - Université de Caen (France).

1998-1999 Collaboration with Lab of Prof. D'Armiento University "la Sapienza" of Rome for the project granted (PRIN): "Molecular effects of thyroid hormone on gonads". 

1999 Visiting research scientist (January) - Lab of Prof. Sassone-Corsi - Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) CNRS - INSERM - Université Louis Pasteur - Strasburg (France).

2000 Visiting research scientist (May) Lab of Prof. Rainey, Department of Obstetrics and Gynecology - Division of Reproductive Endocrinology – UT SW Medical Center - Dallas - Texas.

2001 Visiting research scientist (February) Lab of Prof. Mathis del Department of Cellular Biology and Anatomy- Lousiana State University Medical Center at Shreveport (Lousiana). NATO Award for collaborative Research Program

2001 Visiting research scientist (September - October) Labs of Profs. Rainey and Carr - Department of Obstetrics and Gynecology - Division of Reproductive Endocrinology – UT SW Medical Center - Dallas - Texas. Short-term mobility fund granted by C.N.R.

2001-2002 Collaboration with Lab of Prof. D'Armiento, University "La Sapienza" Rome for the project granted (PRIN 2001): "Mechanisms of regulation of aromatase expression and apoptosis in testis".

From 2003 Collaboration with Labs of Dr. Clyne and Prof Simpson - Prince Henry’s Institute of Medical Research - Clayton-Melbourne (Australia), on projects investigating molecular mechanisms regulating aromatase gene expression in several tissues.

2004-2005 Collaboration with Lab of Prof. Andò Unical for the project granted (PRIN 2004): "Biomolecular mechanisms involved in the pathogenesis of testicular tumors".

2008-2011 Collaboration with Lab of Prof. Carreau, Research Director of CNRS, Chairman unit EA 2608-USC 2006 INRA Dep. Biochimie-IRBA Université de Caen (France) on a project investigating the role of new estrogen receptor GPR30 (GPER) in rat testis.

2012-2016 Member of the Operational Unit coordinated by Prof. Francesco Fallo of the project entitled: “Study of molecular markers for the diagnosis and prognosis and the development of new therapeutic strategies for cancer of the adrenal gland. National Project Coordinator: Prof. Massimo Mannelli (University of Firenze), funded by "FIRB AGREEMENT PROGRAM 2011". 

From 2014 - Today Collaboration with lab of Prof. Lisanti - Breakthrough Breast Cancer Research Unit and the Manchester Centre for Cellular Metabolism, Institute of Cancer Sciences, University of Manchester, UK.

2015 Visiting Professor (October) Department of Molecular & Integrative Physiology and Internal Medicine Endocrine Neoplasia Basic Research Unit -University of Michigan in Ann Arbor.

 

MEMBERSHIPS

European Network ENS@T (European Network for the Study of Adrenal Tumors)

Endocrine Society (USA)

Italian Association of Biology and Genetics (AIBG)

Italian Society of Toxicology of Reproduction

Italian Society of Andrology and Medicine of Sexuality

Italian Society for Endocrinology

 

PEER REVIEWER ACTIVITY 
Associated Editor for: Frontiers in Endocrinology section Cancer Endocrinology
Editorial Board for: ISRN Endocrinology

 

Member of Reviewing Committees of the following journals:

Oncotarget, Molecular and Cellular Endocrinology, Oncogene, Frontiers in Genetics, Journal of Endocrinology, Endocrinology, Oncology, Molecular Medicine, American Journal of Cancer Research, Comparative Biochemistry and Physiology, Journal of Toxicology and Environmental Health Sciences, Molecular Nutrition and Food Research, Enviromental Health and Perspective, BMC Cancer, Cell Death and Disease.

research fields

Study of the molecular mechanisms that regulate the production of estrogens and their role in the onset and progression of endocrine-dependent tumors.

Study of the regulation of steroidogenic enzymes expression in human adrenal cell models.

Study of regulatory factors of spermatogenesis and functionality of the male gamete with particular reference to the role of estrogens and xenoestrogens.

Study of the role of estrogenic receptors and related pathways in the progression of adrenal, testicular and breast cancers.

Characterization of the molecular mechanism of bioactive substances present in food with particular reference to olive oil.

Design and validation of the biological effects of innovative molecules that can be used as active ingredients in the formulation of cosmetics and nutraceuticals.

 

ACTIVITIES IN THE FIELD OF TECHNOLOGY TRANSFER

 

Since 2010, Prof. Pezzi is founder of Macrofarm srl a spin-off company of the University of Calabria that deals with the design, validation of biological effects and production of innovative raw materials that can be used as active ingredients in the formulation of drugs, cosmetics and nutraceuticals.

 

Publications

https://www.ncbi.nlm.nih.gov/pubmed/?term=Pezzi+V

http://www.scopus.com/inward/authorDetails.url?authorID=6701527523&partnerID=MN8TOARS

 

teaching activity

 

Teaching Unit 1

NUTRIENTI E FUNZIONI CELLULARI - METODI PER LO STUDIO DEGLI EFFETTI DEI NUTRIENTI SUI PROCESSI CELLULARI

CLM: SCIENZA DELLA NUTRIZIONE

https://www.unical.it/portale/portaltemplates/view/view_scheda_insegnamento.cfm?45144&LANG=ITA&45144&LANG=ITA

 

Teaching Unit 2

BIOLOGIA CELLULARE E ANATOMIA UMANA

MODULO DI BIOLOGIA CELLULARE

CLM FARMACIA

 

https://www.unical.it/portale/portaltemplates/view/view_scheda_insegnamento.cfm?45519&LANG=ITA&45519&LANG=ITA

 

Teaching Unit 3

BIOLOGIA COMPUTAZIONALE, GENOMICA E PROTEOMICA

CLM Ingegneria Informatica

file:///C:/Users/Vincenzo/Downloads/LM%20INGEGNERIA%20INFORMATICA%2019-20%20(4).pdf

 

THESES

Supervisor of over n. 100 theses in the following Degree and specialization courses of the University of Calabria:

-  experimental for CdL students in Pharmaceutical Chemistry and Technology, in Pharmacy, Master of Science in Nutrition, School of Specialization in Clinical Pathology

-  compilations for students of the Degree Course in Pharmacy, Nutrition Sciences, Magisterial Nutrition Sciences

 

EDUCATIONAL ACTIVITIES IN THE CONTEXT OF PHD PROGRAMS (DOCTORATE)

-  Since 1999 Member of the Academic Board of the Doctorate in "Cellular Biochemistry and Drug Activities in Oncology" activated at the Pharmaceutical-Biological Department of the University of Calabria. Where he did teaching and tutoring activities for several PhD students.

-  Since November 2013 Member of the teaching staff and of the 16 reference components of the doctorate in "Translational Medicine" activated at the Department of Pharmacy and Health and Nutrition Sciences of the University of Calabria. Where he did teaching and tutoring activities for several PhD students.

 

Teaching unit in Applied Biology held in following 1st and 2nd level University Masters

• II level Master in "Quality control manager of the biological and biotechnological agro-food chain (QCM)"

• II level Master in "Nutrition and nutraceutical integration"

• II level Master in "Food and human nutrition: from biology to the clinic"

• II level Master in "Research and Innovation Manager"

• II level Master in "Nutraceutical integration: from wellness to care"

• I level Master in "Innovative therapeutic applications through the phytochemical and pharmacological-biological characterization of plants of traditional Chinese medicine"

• I level Master in "Application aspects of nutrition and clinical nutrition"