DFSSN

Dipartimento di
Farmacia e Scienze della Salute e della Nutrizione
Dipartimento di Eccellenza L. 232/2016

  • Dipartimento di Farmacia e Scienze della Salute e della Nutrizione

 

 

 

 

 

 

 

 

Prof Anna Maria MUSTI

 

education

1979-81 Fogarty fellowship program Lab. of Biochemistry of NCI, NIH, Bethesda, MD. USA

1978      Doctor in Biology at the University of Naples “Federico II”, Italy

professional experience

2008-18 Visiting Scientist at the Institute for Clinical Neurobiology, University of

Wu?rzburg, Germany

1999-present Associate Professor in “ General Pathology” at Dept. of Pharmacy, Health and

Nutrition Sciences, University of Calabria, Rende (CS) Italy

1994-98 Visiting Scientist at EMBL-Heidelberg, Germany

1990-92 Visiting Ass.Prof. Institute of Cancer Research, Columbia University, NY. NY. USA

1983-99 Research investigator at "Centro di Endocrinologia e Oncologia Sperimentale

CNR Naples, Italy

research fields

Regulation of c-Jun/Ap-1 multisite phosphorylation

c-Jun is a major component of the transcription factor AP-1, a paradigm for transcriptional response to extracellular signals. c-Jun activation by N-terminal multisite phosphorylation mediates the nuclear response of MAPK signaling in many different organisms, giving rise to very different cellular responses, including cell cycle progression, differentiation and apoptosis. In turn, deregulation of c-Jun activation may give rise to pathological conditions, including tumor progression, neuroinflammation and degenerative loss of neurons. We have focused on the regulation of c-Jun multisite phosphorylation and its possible role in the diverse outputs of c-Jun biological activity. Our studies in cerebellar granule cells, Bergmann glial cells and breast cancer cells have shown that the extent of c-Jun N-terminal multisite phosphorylation by JNK reflects the degree of extracellular signals and plays an important role in determining the type of c-Jun biological output.

Currently, we are interested to assess how cellular signaling pathways regulates c-Jun/Ap-1 activation in the tumor microenvironments, particularly in tumor-infiltrating T cells, where c-Jun/AP1 cooperates with the NAFAT transcription factor to induce a gene expression profile associated with cytotoxic T cell activation. 

 

Signaling pathways downstream GPER in breast cancer cells and cancer-associated fibroblasts.

We have discovered a functional cross-talk between GPER and Notch signaling both in breast cancer cells and CAFs. In particular, we demonstrated that E2/GPER signaling induced ligand-independent activation of Notch1 and Notch target genes, including the EMT-transcription factor Snail, whose activation required the tripartite NICD-CSL-MALM-1 transcriptional complex. Most importantly, breast cancer cells acquired invasion properties and lost Cadherin expression in a GPER/Notch dependent fashion

Publications

https://orcid.org/0000-0003-1443-2739

teaching activity

2013-now Course of “ General Pathology” (Bachelor Degree in Nutritional Science) at the

Dept. of Pharmacy, Health and Nutrition Sciences, University of Calabria, Italy

2011-14 Course of “Experimental Oncology” and Couse of “ Molecular Pathology “

(Master degree in Pharmacy) Faculty of Pharmacy, University of Calabria, Italy

2000-18 PhD program “Translational Medicine”, previously named ”Cellular biochemistry

and activity of pharmacological molecules in oncology” Department of Pharmacy,

Health and Nutrition Sciences, University of Calabria, Italy

2000-10 Course of “General Pathology” (Bachelor in Environmental Toxicology) at the

Faculty of Pharmacy, University of Calabria, Italy

 

  Teaching Unit

 “Patologia generale e clinica” corso di Laurea triennale in SN della Unical

 “General and Clinical Pathology” (Bachelor Degree in Nutritional Science) at the

  Dept. of Pharmacy, Health and Nutrition Sciences, University of Calabria, Italy