DFSSN

Dipartimento di
Farmacia e Scienze della Salute e della Nutrizione
Dipartimento di Eccellenza L. 232/2016

  • Dipartimento di Farmacia e Scienze della Salute e della Nutrizione

 

 

 

 

 

 

 

 

Prof Antonella LEGGIO

 

education

1998: PhD in Chemical Sciences at the University of Bologna

1994: Master’s degree in Chemistry at the University of Calabria

In 1991 she studied for six months at the Complutense University of Madrid Spain

professional experience

Since November 2010 to date:  Associate Professor of Organic Chemistry at the Department of Pharmacy, Health and Nutritional Sciences of University of Calabria.

Since December 2017 to date: Coordinator of a research unit of the "NANOCAL" Project resulting from a collaboration agreement between NanoSiliCal Devices and the UNIVERSITY OF CALABRIA - Department of Pharmacy and Health and Nutrition Sciences and Department of Environmental and Land Engineering and Chemical Engineering.

Since November 2017 to date: coordinator of the research group of "Organic and Bioorganic Chemistry" at the laboratory of Organic and Biorganic Chemistry of the Department of Pharmacy and Health and Nutrition Sciences of the University of Calabria (UNICAL).

From September 2016 to February 2017: Co-responsible, as co-founder and Managing Consultant of NanoSiliCal Devices, of the European Project "NanoSil4Cancer: Smart Multifunctional silica-based Nanoparticles for Targeted Therapy", funded within the framework of the H2020 Program (Call SME instrument phase 1, TOPIC: "Supporting innovative SMEs in the healthcare biotechnology sector")

Since July 2014 to date: Co-founder and Managing consultant of NanoSilical Devices, a spin-off at the University of Calabria, Department of Pharmacy, Health and Nutritional Sciences, whose main focus is the development of mesoporous silica-based nanosystems to be exploited as a new generation of smart vehicles for targeted chemotherapy (http://www.nanosilicaldevices.com/it/).

Progetto PRIN 2007, Protocollo MIUR:2007N9A3A4_002 dal titolo: “Preparazione di sistemi multifunzionali a base di silice mesoporosa ibrida per il targeting di agenti antineoplastici ” Unità locale: Prof. Rosario Aiello, Dott. Luigi Pasqua, Dott.ssa Antonella Leggio; Coordinatore scientifico TASSONE Pierfrancesco (Università degli Studi “Magna Grecia” di Catanzaro); Altre sedi partecipanti: Università di Napoli, Università Cattolica di Roma, Università Bicocca di Milano. Ammesso al cofinanziamento

From September 2002 to October 2010: Researcher in Organic Chemistry at the Department of Pharmacy, Health and Nutritional Sciences of University of Calabria

managerial/department role

Member of Quality Committee- Third Mission at the Department of Pharmacy SSN

research fields

Research activity covers different organic chemistry topics, including synthetic method development of organic molecules and peptide synthesis. The activities also span drug delivery systems development and analytical organic chemistry.

The main research topics are the following:

 

Development of new methodologies based on the use of Lewis acids and their application to the syntheses of organic molecules of general interest.

Synthesis, both in solution and on solid supports, of peptides and peptidomimetics for use as receptor ligands, anticancer drugs or enzymatic inhibitors.

Development of new solution-phase methods for peptide synthesis

 Synthesis of modified amino acids to be used as "building blocks" for obtaining biologicaly active peptides

Design and synthesis of multifunctional hybrid Mesoporous silica-based systems for targeting and release of biologically active molecules.

Solid-phase synthesis of bioactive oligopeptides present in food products to be used for  preparing "functional foods"

Determination of organic molecules in complex matrices by Mass Spectrometry coupled to chromatographic separation techniques also by using solid phase microextraction (SPME).

Publications

https://orcid.org/0000-0002-4373-6232

Scopus Author ID: 7004306379.

teaching activity

Several Organic Chemistry courses at the Department of Pharmacy, Health and Nutritional Sciences of University of Calabria.

Seminars for PhD courses and lectures by invitation for schools and research institutes and advanced training masters. He has also been supervisor of numerous experimental Degree Theses and supervisor of PhD Theses.

 

Teaching Unit

Since 1997-98 to date: “Chemistry of Natural Organic Substances”, “Laurea Magistrale” in Pharmacy https://www.unical.it/portale/portaltemplates/view/view_scheda_insegnamento.cfm?66325&LANG=ITA&66325&LANG=ITA

 

Since 2016-17 to date: “Organic Chemistry I”, “Laurea Magistrale” in CTF https://www.unical.it/portale/portaltemplates/view/view_scheda_insegnamento.cfm?66370&LANG=ITA&66370&LANG=ITA

 

2002-2003 to 2003-2004; 2014-2015 to 2015-2016; 2018-2019 to date: “Organic Chemistry”, “Laurea triennale ” in SN https://www.unical.it/portale/portaltemplates/view/view_scheda_insegnamento.cfm?71833&LANG=ITA&71833&LANG=ITA

 

2013-2014: “Physical methods in organic chemistry I” “Laurea triennale” in SN

2012/2013: “Chemistry of Natural Organic Substances” “Laurea Specialistica ” in CTF

2006-2007 to 2013-2014: “Bioorganic Chemistry” “Laurea Specialistica ” in CTF

2006-2007 to 2013-2014: “Bioorganic Chemistry” “Laurea Specialistica ” in CTF

2007-2008 to 2011-2012: “Advanced Spectrometric Methodologies in Organic Chemistry I” “Laurea Specialistica ” in CTF

2005-2006 to 2006-2007: “Physical methods in organic chemistry I” “Laurea Specialistica ” in CTF

2005-2006 to 2006-2007: “Physical methods in organic chemistry II” “Laurea Specialistica ” in CTF

2002/2003 to 2003-2004: “Organic Chemistry II”, “Laurea Specialistica ” in CTF