DFSSN

Dipartimento di
Farmacia e Scienze della Salute e della Nutrizione
Dipartimento di Eccellenza L. 232/2016

  • Dipartimento di Farmacia e Scienze della Salute e della Nutrizione

 

 

 

 

 

 

 

 

Prof Vincenza DOLCE

 

education

Master Degree in Biological sciences

Fellowship of National Research Council (CNR) Centro Studi Mitocondri e Metabolismo Energetico.

PhD in Biochemistry and Molecular Biology University of Catania

professional experience

January 1994 – December 1996 Technical assistant University of Bari

December 1996 –May  2001 Researcher in biochemistry University of Calabria

June 2001- November  2012 Associate professor in Biochemistry University of Calabria

December 2012 – Today Full professor in Biochemistry University of Calabria

1990 Visiting scientist at MRC, Laboratory of Molecular Biology, Cambridge, U.K. under the supervision of the Nobel Prize, Sir. John E. Walker

1997 Visiting scientist at MRC, Laboratory of Molecular Biology, Cambridge, U.K. under the supervision of the Nobel Prize, Sir. John E. Walker

managerial/department role

Coordinator of the Bachelor Degree in Nutritional Science at the University of Calabria (2011-today)

research fields

Prof. M. Dolce has a longstanding interest in mitochondrial bioenergetics and cell metabolism. Her studies have mainly been focused on the functional characterization of a family of proteins of the inner mitochondrial membrane, which shuttle metabolites, nucleotides, ions and cofactors through this membrane, and connect mitochondrial pathways with others in the cytosol. As young researcher in UK, she had the privilege to be tutored by great scientists in the mitochondrial bioenergetics and cell metabolism fields such as the Nobel Prize Sir. John E. Walker who participated in different ways to his career development. In 1996, she set up a new experimental approach for the functional identification of the mitochondrial carriers based on the reconstitution of the bacterial recombinant protein into liposomes. Since then, professor Dolce’s group has become the worldwide renown group with respect to the mitochondrial carriers with more than 10 of these proteins characterized by reconstitution experiments coupled to cellular studies. She mainly works on the identification and characterization of enzyme and membrane transport systems, in particular on the functional characterization of mitochondrial carrier family members in Homo sapiens and model organism Drosophila melanogaster. Her experience and unique technical skills in this field supports many clinicians and geneticists to shed lights on the metabolic phenotypes of many human diseases due to the deficiency of a mitochondrial carrier, such as type II citrullinaemia (OMIM, 603471), Amish microcephaly (OMIM, 607196). Furthermore she studied the hypercholesterolemic activity of natural and synthetic compounds in in vivo studies acquiring the main advanced techniques in cell biology and animal model.

Since 2009, in the papers of functional characterization of the mitochondrial carriers prof Dolce is corresponding author.

Publications

https://orcid.org/0000-0003-2966-4866)

teaching activity

Teaching Unit BIOCHEMISTRY Degree course (CdS) Science of Nutrition

Teaching Unit BIOCHEMISTRY Degree course (CdS) Pharmaceutical Chemistry and Technology

Teaching Unit

Biochemistry

https://www.unical.it/portale/portaltemplates/view/view_scheda_insegnamento.cfm?66431&LANG=ITA&66431&LANG=ITA

Biochemistry https://www.unical.it/portale/portaltemplates/view/view_scheda_insegnamento.cfm?66372&LANG=ITA&66372&LANG=ITA