DFSSN

Dipartimento di
Farmacia e Scienze della Salute e della Nutrizione
Dipartimento di Eccellenza L. 232/2016

  • Dipartimento di Farmacia e Scienze della Salute e della Nutrizione

 

 

 

 

 

 

 

Prof Anna Rita CAPPELLO

 

education

1988: Degree in Biological Sciences, University of Lecce, Italy.

1995: PhD in Cellular Biochemistry and Cellular Pharmacology, University of Bari, Italy.

professional experience

2018: ASN achievement for Full Professor of Biochemistry.

2012-today: Associate Professor of Biochemistry, Department of Pharmacy, Health and Nutritional Sciences -University of Calabria.

2002-2011: University Researcher (SSD BIO/10), Department of Pharmaco-Biology (University of Calabria).

2000-2001: Research Fellowship CIB (Interuniversity Society of Biotechnology), Department of Pharmaco-Biology, University of Bari.

1999-2000: Agreement with the Department Pharmaco-Biology, University of Bari

1997-1999: Postdoctoral Fellowship, Department Pharmaco-Biology, University of Bari.

1995-1996: Fellowship from the National Research Council (C.N.R.) of Italy, Institute of Agro-Food Research and Biotechnology (IRBA), Lecce.

1992-1995: PhD student in Cellular Biochemistry and Cellular Pharmacology; Department of Pharmaco-Biology, University of Bari.

1987-1988: Research undergraduate in biochemistry, Faculty of Sciences, University of Lecce, Italy.

managerial/department role

2014-to date: Deputy cordinator of the Degree in Pharmaceutical Chemistry and Technology.

2016-to date: member of teaching board of Specialization School in "Clinical Biochemistry and Clinical Pathology” of the University of Calabria.

2013-to date: Member of the PhD council in “Translational Medicine”- University of Calabria.

2014-2018: Member of the board of Department of Pharmacy, Health and Nutritional Sciences, University of Calabria.

2014-to date: Member of the committee student-faculty teaching - Department of Pharmacy, Health and Nutritional Sciences -University of Calabria.

2014-to date: Member of Animal Care Committee-Department of Pharmacy, Health and Nutritional Sciences - University of Calabria.

2006-2015: Member of the PhD council in “Cellular Biochemistry and drugs activity in oncology"-University of Calabria.

1997-2001: member of teaching board of Specialization School in "Clinical Pathology” - University of Calabria.

research fields

Investigation on Actinobacteria in order to identify, isolate and characterize new secondary metabolites synthesized by them and able to affect mitochondrial metabolism of cancer cells, thus reducing the formation and propagation of tumor-initiating cells.

Assessment of metabolic reprogramming of the neoplastic cell in the stem cells induction and chemotherapy resistance for the identification of new therapeutic targets.

In vitro” and "in vivo" studies to assess the biological activity of natural compounds as well as newly synthesized molecules and their possible involvement in cell metabolism, in order to identify new nutraceutical compounds and new potential therapeutic agents for severe human diseases.

"In vitro" kinetic studies and functional characterization of membrane transport proteins by a new experimental approach, based on the reconstitution of the bacterial recombinant protein into liposomes, their interaction with commonly used drugs and evaluation of a possible involvement in cell metabolism and in cell differentiation, in order to identify new therapeutic targets;

analysis of the structure-function relationship of membrane transport proteins, by cys-scanning mutagenesis and "homology modeling". This studies shed light on transport mechanism of mitochondrial carrier protein, in order to understand their metabolic role. 

Publications

·  https://www.ncbi.nlm.nih.gov/pubmed/?term=cappello+ar

·  orcid.org/0000-0001-7824-3561

teaching activity

1995-1996: “Biochemical Methodologies”, Master’s Degree Course in Pharmaceutical Chemistry and Technology - University of Calabria.

1996-1999: “Molecular biology”, Master’s Degree Course in Pharmaceutical Chemistry and Technology - University of Calabria.

1999-to date: “Industrial Biochemistry” Master’s Degree Course in Pharmaceutical Chemistry and Technology - University of Calabria.

2002-2012: “Biochemistry” three year Bachelor Degrees in Cosmetic Products Technologies and Environmental Toxicology - University of Calabria.

2003-2005: "Recombinant DNA Technologies", three year Bachelor Degree   in Scientific Information on Drug - Università della Calabria.

2005-2007: "Biochemistry of Pathological States", Master’s Degree Course in Pharmacy - University of Calabria.

2013-to date: "Biochemistry ", Master’s Degree Course in Pharmacy - University of Calabria.

 

Teaching Unit

 

Biochimica/ Biochemistry

Link to  https://www.unical.it/portale/strutture/dipartimenti_240/dfssn/insegnamenti/farmacia/

Biochimica Industriale/Industrial biochemistry

Link to  https://www.unical.it/portale/strutture/dipartimenti_240/dfssn/insegnamenti/ctf/